Wakako Maruyama Selected Research

Selegiline (E250)

1/2020	Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease.
11/2018	Type A and B monoamine oxidases distinctly modulate signal transduction pathway and gene expression to regulate brain function and survival of neurons.
1/2017	Type B and A monoamine oxidase and their inhibitors regulate the gene expression of Bcl-2 and neurotrophic factors in human glioblastoma U118MG cells: different signal pathways for neuroprotection by selegiline and rasagiline.
2/2016	Modulation of monoamine oxidase (MAO) expression in neuropsychiatric disorders: genetic and environmental factors involved in type A MAO expression.
1/2013	''70th Birthday Professor Riederer'' induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (-)deprenyl: a way to a disease-modifying therapy?
4/2012	Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase.
1/2010	Monoamine oxidase inhibitors as neuroprotective agents in age-dependent neurodegenerative disorders.
8/2009	Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease.

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Wakako Maruyama Research Topics

Disease

25	Parkinson Disease (Parkinson's Disease) 01/2022 - 06/2002
17	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2018 - 05/2004
11	Neuroblastoma 11/2018 - 03/2002
8	Alzheimer Disease (Alzheimer's Disease) 11/2018 - 05/2004
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 01/2002
2	Inflammation (Inflammations) 01/2020 - 01/2010
2	Disease Progression 01/2020 - 01/2010
2	Glioblastoma (Glioblastoma Multiforme) 11/2018 - 01/2017
2	Hypoxia (Hypoxemia) 06/2005 - 01/2005
2	Craniocerebral Trauma (Head Injury) 06/2005 - 01/2005
2	Ischemia 06/2005 - 01/2005
1	Neuroinflammatory Diseases 01/2022
1	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2020
1	Prodromal Symptoms 01/2020
1	Mental Disorders (Mental Disorder) 11/2018
1	Depressive Disorder (Melancholia) 01/2018
1	Neoplasms (Cancer) 01/2017
1	Inborn Genetic Diseases (Disease, Hereditary) 02/2016
1	Chronic Renal Insufficiency 02/2010
1	Renal Insufficiency (Renal Failure) 02/2010
1	Lewy Body Disease (Lewy Body Dementia) 05/2003
1	Leigh Disease (Leigh's Disease) 01/2002
1	Neuropathy ataxia and retinitis pigmentosa 01/2002

Drug/Important Bio-Agent (IBA)

15	Monoamine Oxidase (MAO)IBA 11/2018 - 01/2005
14	rasagiline (Azilect)FDA Link 01/2020 - 06/2002
8	Nerve Growth Factors (Neurotrophins)IBA 01/2022 - 08/2009
8	Selegiline (E250)FDA LinkGeneric 01/2020 - 08/2009
8	NeurotoxinsIBA 03/2013 - 03/2002
6	Neuroprotective AgentsIBA 01/2022 - 05/2004
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2003
5	salsolineIBA 05/2004 - 08/2002
4	Dopamine (Intropin)FDA LinkGeneric 01/2020 - 09/2002
4	EnzymesIBA 02/2016 - 01/2002
3	SynucleinsIBA 01/2022 - 05/2018
3	PhytochemicalsIBA 01/2022 - 01/2017
3	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 01/2017 - 01/2010
3	NitrogenIBA 02/2010 - 11/2003
3	Pharmaceutical PreparationsIBA 06/2005 - 06/2002
2	AntioxidantsIBA 01/2022 - 01/2017
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/2018 - 09/2004
2	Docosahexaenoic AcidsIBA 05/2018 - 12/2008
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 05/2018 - 12/2008
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2018 - 05/2004
2	Messenger RNA (mRNA)IBA 02/2016 - 05/2004
2	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 01/2013 - 05/2004
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2012 - 01/2011
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2010 - 11/2003
2	neuromelaninIBA 11/2009 - 06/2008
2	Levodopa (L Dopa)FDA LinkGeneric 06/2005 - 01/2005
2	RotenoneIBA 01/2005 - 11/2003
2	Acrolein (Aqualin)IBA 01/2005 - 11/2003
2	Oxygen (Dioxygen)IBA 01/2005 - 11/2003
1	LipidsIBA 05/2018
1	Lysine (L-Lysine)FDA Link 05/2018
1	Indicators and Reagents (Reagents)IBA 05/2018
1	Serotonin (5 Hydroxytryptamine)IBA 01/2018
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2018
1	Lipid PeroxidesIBA 01/2014
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2013
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2011
1	Urea (Carbamide)FDA LinkGeneric 02/2010
1	CreatinineIBA 02/2010
1	MineralsIBA 02/2010
1	Collagen Type I (Type I Collagen)IBA 02/2010
1	CalciumIBA 02/2010
1	Parathyroid Hormone (Parathormone)IBA 02/2010
1	Adenine FDA LinkGeneric 02/2010
1	1,25-dihydroxyvitamin DIBA 02/2010
1	collagen type I trimeric cross-linked peptideIBA 02/2010
1	Arachidonic Acid (Vitamin F)IBA 12/2008
1	Biogenic Amines (Biogenic Amine)IBA 01/2005
1	AldehydesIBA 01/2005
1	LigninIBA 09/2004
1	Caspase 8 (Caspase-8)IBA 09/2004
1	Caspase 9IBA 09/2004
1	Caspase 3 (Caspase-3)IBA 09/2004
1	NF-kappa B (NF-kB)IBA 05/2004
1	Transcription Factors (Transcription Factor)IBA 05/2004
1	N-propargylIBA 05/2004
1	salsolinol N-methyltransferaseIBA 01/2004
1	AntibodiesIBA 11/2003
1	dityrosineIBA 11/2003
1	CarbamatesIBA 05/2003
1	Cholinesterases (Cholinesterase)IBA 05/2003
1	Amino Acids FDA Link 11/2002
1	Cytochromes b (Cytochrome b)IBA 11/2002
1	MethyltransferasesIBA 09/2002
1	salsolinolIBA 09/2002
1	Cytochromes c (Cytochrome c)IBA 08/2002
1	Oxidopamine (6 Hydroxydopamine)IBA 03/2002
1	DNA Restriction Enzymes (Restriction Endonuclease)IBA 01/2002
1	Protons (Proton)IBA 01/2002

Therapy/Procedure

8	Therapeutics 01/2020 - 09/2002